SAM pointed domain containing ETS transcription factor: A Pro- and Anti-Oncogenic agent in Breast Cancer

Author: Nootan Singh, Juveriya Israr and Divya Gupta

Download PDF

Abstract

SPDEF (SAM pointed domain containing ETS transcription factor) maintains homeostasis and differentiation of epithelial tissues and heritable alteration in cancer. SPDEF is a prostate-derived ETS factor that has been demonstrated to have a role in normal cell growth and development and also in cell survival. This transcription factor also plays a significant role in possessing dual malignancy characteristics. Breast cancer (BC) is a complex heterogeneous disease associated with multiple structures that have risen to become the leading source of cancer death in women worldwide. SPDEF has been linked to a variety of characteristics of BC. The mechanism governing SPDEF's pro- and anti-oncogenic effects in the BC state is yet unknown. If SPDEF is shown to significantly affect breast cancer, comprehension of its molecular mechanisms would be necessary to target it therapeutically. It is challenging to create treatments that regulate SPDEF activity while reducing side effects. In this study, we reviewed SPDEF's role as a multipurpose agent in expression levels, the regulation process in BC development, and its role in BC diagnosis, therapy, and prediction. Knowing SPDEF duality has assisted in getting knowledge into tumor biology as well as giving new BC treatment targets a new perspective.

Keywords

Breast Cancer, ETS, SPDEF, Oncogene, Tumor suppressor gene

Conclusion

SPDEF has drawn a lot of attention due to its role in oncogenesis and growth. The concept of SPDEF has been problematic in the dichotomy of cancer-regulatory genes. It is more feasible to treat SPDEF as a dual-functional gene after thoroughly summarising current findings, which will aid in understanding breast cancer heterogeneity and facilitate future research. The mechanism underlying SPDEF's regulation must be investigated given that we have a better understanding of its dual-functional nature. This is crucial for developing personalized therapy for each BC subtype. In the not-too-distant future, SPDEF could become a novel diagnostic and therapeutic target in breast cancer biology.

References

-

How to cite this article

Nootan Singh, Juveriya Israr and Divya Gupta (2023). SAM pointed domain containing ETS transcription factor: A Pro- and Anti-Oncogenic agent in Breast Cancer. Biological Forum – An International Journal, 15(5a): 412-420.