Synthesis, Anticancer Activity and Molecular Docking Study of Some Novel 1,3,5-Triazine Derivatives

Author: Ridhima Chauhan and Girdhar Pal Singh

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Abstract

A crucial field of medical research is the study of cancer medications. New medications that can target and cure various forms of cancer are constantly being developed by researchers and pharmaceutical firms. A series of some novel triazine derivatives has been synthesized and screened them for cancer activity against human breast (MCF-7), cervical cancer (C33A), oral (KB) and prostrate (DU-145). The structures of the synthesized compounds were confirmed bn IR, Mass and 1H NMR Sectra. The compounds showed 1b 1e, 1f, 1h and 1j showed significant anticancer activity. The docked compounds 1e, 1f, and 1j (-8.4, -8.4, -8.5) that had the highest binding affinity against the PDB ID: 1XKK. This can possibly lead to emergence of new anticancer agents.

Keywords

Triazines, Anticancer, Molecular Docking, human breast (MCF-7,), cervical cancer (C33A), oral (KB) and prostrate (DU-145)

Conclusion

A novel and simple method for the synthesis of triazine derivatives has been developed. Some of the synthesized compounds produced cytotoxic activity against cell lines; human breast (MCF-7,), cervical cancer (C33A), oral (KB) and prostrate (DU-145) in particular, the compounds 6-(methylthio)-4-(quinolin-2-yl)-3,4-dihydro-1,3,5-triazine-2(1H)-thione (1e), 6-(methylthio)-4-(quinolin-3-yl)-3,4-dihydro-1,3,5-triazine-2(1H)-thione (1f) and 4-(isoquinolin-3-yl)-6-(methylthio)-3,4-dihydro-1,3,5-triazine-2(1H)-thione (1j) were found as promising compounds and could serve as leads for further modification to develop clinically useful anticancer agents.

References

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How to cite this article

Ridhima Chauhan and Girdhar Pal Singh (2023). Synthesis, Anticancer Activity and Molecular Docking Study of Some Novel 1,3,5-Triazine Derivatives. Biological Forum – An International Journal, 15(5a): 463-468.