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Factorial Design Formulation Optimization and in vitro characterization of Colon Targeted Delivery System of Azathioprine

Author: Shikha Jakhotiya and Gajendra Singh Rathore

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Abstract

Colon-targeted drug delivery systems are designed to deliver medications specifically to the colon, which can be useful for the treatment of various gastrointestinal disorders. The current work's goal is to develop and optimise an Azathioprine colon focused delivery device. Azathioprine (150g) was manufactured as separate wet masses using a 1:1 ratio of the drug to the polymer in order to create the multiparticulate formulation. As part of the experimental process, 125g of azathioprine, coupled with chitosan and guar gum, were used. Using a standard coating pan and polymethacrylate solutions (namely, Eudragit L100 and Eudragit S100 at concentrations of 10-15% (w/w) each), enteric coating was carried out. Multiparticulate C4 from the optimised batch was placed inside a capsule. The oral colon administration system is a cutting-edge method for treating various diseases. Azathioprine's enhanced colon drug delivery mechanism may be employed for future testing with a view to clinical usage.

Keywords

Formulation, Optimization, Azathioprine

Conclusion

Colon drug delivery system of Azathioprine was successfully prepared and 23 factorial design model was employed to optimize the formulation. The in-vitro drug release of C4 was best explained by the k-peppas equation, which had highest linearity R2 values at 0.9979, 0.9904, and 0.9966. This was followed by the Higuchi equation, which had R2 values at 0.9944, 0.9833, and 0.9850, and First order R2 values at 0.9811, 0.9821, and 0.9852 correspondingly. Then the optimized formulation C4 is suggested for further evaluation.

References

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How to cite this article

Shikha Jakhotiya and Gajendra Singh Rathore (2023). Factorial Design Formulation Optimization and in vitro characterization of Colon Targeted Delivery System of Azathioprine. Biological Forum – An International Journal, 15(5a): 492-505.