An Efficient Procedure for Esterification of certain Aromatic Acids and its Synthetic Utilities

Author: Somwanshi A.R.

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Abstract

The esterification of aromatic acids can be promoted by mineral acid (H2SO4) under standard conditions. The desired product was separated by simple extraction method. Here we have used ethyl acetate as extracting solvent for the product and water (equimolar quantity). As these esters is the important and initial step for the synthesis benzoflavone (7, 8). So, in this work we have studied the first step for flavone synthesis. And synthesized couple of derivatives with different substituents of aromatic acids and it may lead to the further synthetic route for the formation different moieties of benzoflavones rings having promising biological activities and the structural analysis of these derivatives was confirmed by 1H NMR, 13CNMR and GCMS analysis.

Keywords

Esterification, acetylation, mineral acid, extraction method, aromatic acids

Conclusion

The esterification of different aromatic acids has been carried out with mineral acids (Few drops of H2SO4) as a catalyst. To know the role of different substituents on the aromatic ring. We have synthesized the couple of derivatives. In synthetic route the separation of product was done by simple extraction method with two solvent and brine solutions. Here we have used ethyl acetate (Ester extracting solvent) and water to remove the excess mineral acid. This esterification reaction is a promising and efficient protocol to synthesize several novel esters of substituted aromatic carboxylic acids with different phenols and naphthol’s.

References

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How to cite this article

Somwanshi A.R. (2023). An Efficient Procedure for Esterification of certain Aromatic Acids and its Synthetic Utilities. Biological Forum – An International Journal, 15(5a): 521-526.