Therapeutic Potentials of Mesenchymal Stem Cells

Author: Pavitra Revadi Jain, Vivek R. Kasaralikar, Pradeepkumar Hiremani, B. Roopali, Pavan, Manikya Sai Kiran and Sai Prasanna G.

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Abstract

Regenerative medicine's main tool is mesenchymal stem cells. Multipotent mesenchymal stromal cells, multipotent stromal cells, medicinal signalling cells, and MSCs are other names for mesenchymal stem cells. The primary immunomodulatory mechanisms by which MSCs exhibit their therapeutic qualities are paracrine action, extracellular vesicle (ECV) secretion, apoptosis-mediated immunomodulation, and mitochondrial transfer of membrane vesicles and organelles. MSCs primarily work by causing functional alterations in immune cells through paracrine signalling. ECVs are vesicles that form via inward or outward budding from the plasma membrane. The process of phagocytic clearance of dying cells, or efferocytosis, contributes to more than just the healing of damaged tissue and the absence of inflammation. A variety of physiological and pathological processes are linked to mitochondrial transport. One of MSC-based therapies' main benefits is their capacity to repair injured tissue, in addition to their intricate immunomodulation processes.

Keywords

Mesenchymal stem cells, Regenerative Medicine, Paracrine action, Mitochondrial transfer, Apoptosis mediated immunomodulation and Phagocytic clearance

Conclusion

Regenerative Medicine is a budding area in Veterinary Medicine. MSCs are the main tools in the field of regenerative medicine, to use the MSCs properly according to clinical condition it is very important to know the therapeutic potential of MSCs of different origin and different path of action.

References

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How to cite this article

Pavitra Revadi Jain, Vivek R. Kasaralikar, Pradeepkumar Hiremani, B. Roopali, Pavan, Manikya Sai Kiran and Sai Prasanna G. (2023). Therapeutic Potentials of Mesenchymal Stem Cells. Biological Forum – An International Journal, 15(9): 1081-1083.