Synthesis and Pharmacological Activities of Ligustrazine Derivatives: A Review

Author: Pravin Thombare, Anna Pratima Nikalje and Harichandra A. Parbat

Download PDF

Abstract

Ligustrazine, a bioactive alkaloid extracted from Chinese herb Ligusticum chuanxiong Hort, has garnered substantial consideration in recent days because of its diverse pharmacological activities besides therapeutic potential. Developing ligustrazine derivatives can be challenging due to several factors, and there are associated challenges in the synthesis and evaluation of their pharmacological activities. This paper focuses on the synthesis, pharmacological properties, as well as therapeutic applications of ligustrazine derivatives, targeting to deliver a widespread overview of current research in this field. In conclusion, this paper consolidates current knowledge on ligustrazine derivatives, offering valuable insights into their synthesis, pharmacological activities, and therapeutic applications. The exploration of ligustrazine derivatives holds great promise for the development of innovative pharmaceuticals with enhanced therapeutic efficacy and a broader range of clinical applications.

Keywords

Ligustrazine, tetramethylpyrazine, alkylpyrazine, pharmacological activities

Conclusion

The use of natural ingredients is crucial to the drug discovery process. Among these natural products, ligustrazine has been utilized extensively in clinical settings because of the fact that it possesses an extensive range of high-potency antioxidant action and is hypotoxic. As the mechanism of action has been gradually recognized, ligustrazine has evolved into a topical chemical in the study that is currently being conducted.

References

-

How to cite this article

Pravin Thombare, Anna Pratima Nikalje and Harichandra A. Parbat (2023). Synthesis and Pharmacological Activities of Ligustrazine Derivatives: A Review. Biological Forum – An International Journal, 15(10): 674-680.