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Pathological Studies on Granulomatous Nephritis in Pig

Author: Shobha Burdak, Indu Vyas, Hemant Dadhich, Shesh Asopa, Manisha Mehra, Hiteshwar Singh Yadav and Nikhil Pal Bajia

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Abstract

Five hundred and eighty-six kidney samples were screened to establish the diversity of renal disorders in pigs irrespective of age, sex and breed at organised and unorganised farms of Bikaner, Jaipur and Alwar districts of Rajasthan. Out of 586 specimens, total of 154 specimens of kidneys were revealed macroscopic lesions. In two (1.30 per cent) cases of granulomatous nephritis, small sized many granulomas on surface of kidney were processed for further histopathological examination at the Department of Veterinary Pathology, Bikaner. The gross lesion showed miliary granules on the surface kidney. The surface was whitish-grey in colour. The kidney showed yellowish areas surrounded by the large pale zones with the remaining portions of kidneys essentially normal. Histopathological examination revealed multiple nodular aggregations of epithelioid-like macrophages and multinucleate giant cells. Severe expansion of the interstitium by inflammatory cells, consisting predominantly of lymphocytes and eosinophils was present.

Keywords

Granulomatous Nephritis, Pig, Histopathology, Staining

Conclusion

The study focused on histopathology of kidneys among pigs. Investigational parameters like tubular degeneration and granulomas were considered as significant changes that occur during advanced stages of chronic kidney disease, compared with early stages of the disease. The histopathology findings can help elucidate the reason behind this condition might be parasitic infection or allergic reactions. These indications will help out to identify therapeutic targets and the stages of disease at which they should be initiated.

References

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How to cite this article

Shobha Burdak, Indu Vyas, Hemant Dadhich, Shesh Asopa, Manisha Mehra, Hiteshwar Singh Yadav and Nikhil Pal Bajia (2024). Pathological Studies on Granulomatous Nephritis in Pig. Biological Forum – An International Journal, 16(1): 79-81.