Efficacy of Extracts of Anthocephalus cadamba, Brassica juncea and Pithecellobium dulce against Fipronil-induced Histopathological Changes in Wistar Rats

Author: Devendra Singh, Pratishtha Sharma, Shweta Anand, Rahul Swarnkar and Naresh Singh Kuntal

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Abstract

Fipronil is a new generation broad spectrum insecticide of phenylpyrazole group used for pest management in agriculture practices widely. The current study aimed to assess the ameliorating effects of Anthocephalus cadamba (Kadamba), Brassica juncea (Mustard), and Pithecellobium dulce (Jungle jalebi) extracts on histopathological changes induced by sub-acute Fipronil exposure in rats. Rats of either sex were randomly divided into five groups (6 rats/group). Group I served as a control in which corn oil (acting as a vehicle of Fipronil) was administered @10 ml/kg body weight daily for 28 days. Group II served as Fipronil treated group @10 mg/kg body weight, daily for 28 days. Fipronil along with extracts of Anthocephalus cadamba leaves, Brassica juncea seeds and Pithecellobium dulce fruits @300 mg/kg body weight, daily for 28 days were administered in groups III, IV, and V, respectively. Histopathological findings revealed that fipronil produced mild to moderate degenerative changes in the liver, kidney, brain, and spleen which were minimized by the co-treatment with Kadamba, Mustard, and Jungle jalebi in fipronil-intoxicated rats. Extracts of all three plants were found effective to ameliorate the histopathological alterations of major organs affected by sub-acute toxicity induced by fipronil in rats. Among these, extract of Pithecellobium dulce fruits exhibits the highest ameliorative potential compared to Anthocephalus cadamba leaves, Brassica juncea seeds extracts.

Keywords

Kadamba, Mustard, Jungle jalebi, fipronil

Conclusion

The histopathological findings indicated that fipronil induced mild to moderate degenerative changes in the liver, kidney, brain, and spleen, which were subsequently reversed by the co-treatment with the extracts of Kadamba, Mustard, and Jungle Jalebi. Observations revealed that the group treated with Pithecellobium dulce (Jungle Jalebi) exhibited a superior ameliorative effect compared to the other treatment groups.

References

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How to cite this article

Devendra Singh, Pratishtha Sharma, Shweta Anand, Rahul Swarnkar and Naresh Singh Kuntal (2024). Efficacy of Extracts of Anthocephalus cadamba, Brassica juncea and Pithecellobium dulce Against Fipronil-induced Histopathological Changes in Wistar Rats. Biological Forum – An International Journal, 16(1): 120-124.