Formulation and Evaluation of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate In-situ Ocular Gel

Author: Santanu Ghosh and Kamal Singh Rathore

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Abstract

The objective of our research was to create an ocular gel comprising Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate in order to enhance its bioavailability when applied to the surface of the eye. An in-situ ocular gel was created using a temperature-sensitive gelling agent called Kolliphor 407, along with a viscosity building polymer known as HPMC K100. The selection of polymer quantities was based on the optimal amount needed for the prolonged release of the medication from the preparation. This was determined by consulting relevant literature and conducting a comprehensive investigation with varying amounts. The temperature-triggered in-situ ocular gel was prepared using Kolliphor 407 and HPMC K100 polymer. The evaluation of all formulations included assessments of their appearance, pH levels, viscosity at various pH levels, gelling capacity, percentage of drug content, and release research. 32 factorial designs were used to successfully prepare and optimize nine formulations. The optimization process was performed using DoE software, namely Version 13.0.10.064. Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate were effectively synthesized in a temperature-triggered in-situ gelling system employing Kolliphor 407 in combination with HPMC K100. The significance of HPMC K100 and Kolliphor 407 in the in-situ gel behavior is witnessed based on primary influence of the concentration of HPMC K100 and Kolliphor 407. The in-vitro findings suggest that the in-situ gel system can effectively replace traditional ocular drops due to its capacity to provide a continuous delivery of medication.

Keywords

Kolliphor 407, HPMC, temperature trigged in-situ ocular gel and bioavailability.

Conclusion

The combination of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate was effectively incorporated into a temperature-responsive in-situ gelling system. This system utilized Kolliphor 407 in conjunction with HPMC K100. The significance of HPMC K100 and Kolliphor 407 in influencing in-situ gel behavior was observed based on concentration of HPMC K100 and Kolliphor 407. The in-vitro findings suggest that the in-situ gel system can serve as a practical substitute for traditional ocular drops due to its capacity to maintain a continuous flow of medication.

References

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How to cite this article

Santanu Ghosh and Kamal Singh Rathore (2023). Formulation and Evaluation of Moxifloxacin Hydrochloride and Dexamethasone Sodium Phosphate In-situ Ocular Gel. Biological Forum – An International Journal, 15(5a): 695-707.