In vitro anticancer activity of Launaea procumbens (Roxb.) against different cancer cell lines

Author: Deepa K.N. and D. Kotresha

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Abstract

The present study focuses on Launaea procumbens, a wild plant from the Asteraceae family, commonly found as a weed in maize and onion fields. It is utilized for treating different health conditions such as liver and kidney disorders, antifungal issues, antioxidant benefits, and cardio-protective properties. Additionally, in certain regions, it is consumed as a food item in the form of a salad. The plant samples were collected from maize fields in and around Davangere district, Karnataka. The primary aim is to conduct a phytochemical analysis, GCMS profiling, and assess anticancer activity against four different cancer cell lines. Phytochemical analysis involved three different solvents for extracting compounds derived from the aerial parts of the plant. The identification of chemical compounds was carried out using GCMS analysis from chloroform and methanol extracts. Cytotoxicity against four cancer cell lines (NCIH-460, MDAMB-231, K562, and HePG2) was evaluated using MTT assay with three different solvents of plant extracts. Phytochemical analysis revealed the presence of various components, indicating the existence of phytoconstituents like alkaloids, saponins, tannins, proteins, phenols, and terpenoids, glycosides and carbohydrates. GCMS analysis of plant extracts of chloroform and methanol revel the presence some active compounds and these are responsible for anticancer activity against selected cancer cell lines. Out if four cancer cell lines, MDAMB-231 and NCIH-460 shows good cytotoxic activity with IC50 values are 45.23 µg/ml and 35.23 µg/ml, respectively. Launaea procumbens was possess some significant secondary metabolites and exhibited potential as an anticancer agent against four different cancer cell lines. However, additional research is necessary to find out particular compounds responsible for its anticancer properties, and additional investigations are needed to elucidate its molecular mechanisms

Keywords

Launaea procumbens, Aerial part, phytochemical analysis, GCMS, MTT assay

Conclusion

The current study regarding to cytotoxic and anticancer activity of aerial part of Launaea procumbens methonlic extract showed strong anticancer activity. Among four cancer cell lines, two cell lines such as MDAMB-231 and NCIH-460 showed good cytotoxic activity. The GCMS analysis provides evidence that presence of some bioactive compounds in methonlic and chloroform extract

References

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How to cite this article

Deepa K.N. and D. Kotresha (2023). In vitro anticancer activity of Launaea procumbens (Roxb.) against different cancer cell lines. Biological Forum – An International Journal, 15(6): 882-890.