Therapeutic Potential of Naringin and Resveratrol in Mitigating Cognitive Dysfunction in STZ-Induced Diabetic Rats

Author: Prashant V. Tapadiya and Kuldeep S. Patel

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Abstract

Cognitive dysfunction is a major health issue, affecting people of all ages with impairments ranging from mild memory problems to severe conditions like dementia. Diabetes mellitus, a critical metabolic disorder, leads to severe complications such as visual impairment, neuropathy, cardiovascular disease, and end-stage renal disease. Less recognized is its profound impact on cognitive function, with both type 1 and type 2 diabetes patients experiencing cognitive deficits. Chronic hypoglycemia and hyperglycemia are known to impair cognitive functions, raising concerns about their long-term effects on memory and overall cognitive health. This study investigated the therapeutic effects of naringin and resveratrol on cognitive dysfunction induced by streptozotocin (STZ) in Wistar rats. Diabetes was induced in the rats via STZ administration, followed by treatment with naringin, resveratrol, or a combination of both. Cognitive function was evaluated using the Elevated Zero Maze for anxiety assessment, Morris Water Maze for spatial memory and learning, and the Open Field Test for general locomotor activity. The results showed that naringin and resveratrol, administered individually or in combination, significantly improved cognitive performance and reduced anxiety in diabetic rats. The combination therapy was particularly effective, suggesting enhanced cognitive function and emotional well-being compared to the control and individual treatment groups. These findings highlight the potential of naringin and resveratrol as promising therapeutic agents for managing cognitive impairments associated with diabetes and metabolic disorders. Overall, this study provides valuable insights into the benefits of naringin and resveratrol, offering a basis for further research into their therapeutic applications for diabetes-related cognitive impairments

Keywords

Reservetrol, Naringenin, Cognitive dysfunction, Diabetes, Streptozocin

Conclusion

The combination of naringin and resveratrol markedly enhanced cognitive function and reduced anxiety in STZ-induced diabetic rats. These findings indicate that naringin and resveratrol have potential as therapeutic agents for treating cognitive impairments linked to diabetes and metabolic disorders

References

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How to cite this article

Prashant V. Tapadiya and Kuldeep S. Patel (2023). Therapeutic Potential of Naringin and Resveratrol in Mitigating Cognitive Dysfunction in STZ-Induced Diabetic Rats. Biological Forum – An International Journal, 15(6): 891-897.