Red Grape Seed Extract (RGSE) has a Positive Effect on Systemic Organ Dysfunctions Caused by Long-Term Exposure to D-galactose (IP) in the Alzheimer's Disease Rat Model

Author: H. Rama Subba Reddy, M. Vijaya Kumar and V. Uday Kiran

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Abstract

Objectives: The purpose of the study is to investigate the effects of D-Galactose exposure on cognitive, motor, physical, and organ dysfunction in Alzheimer's disease rats. Materials and Methods: A total of 48 healthy male Wistar rats (Rattus norvegicus) aged 3 months, weighing approximately 180±20g. Rats were divided into four groups and treated with intraperitoneal (i.p.) injections of D-Galactose (120 mg/kg body weight) dissolved in distilled water. Experiments were conducted for 30 and 60 days. Cognitive Functions Evaluated using Y maze, nest building, and Morris water maze tests. Motor Functions: Assessed using wire hang and rotarod tests. Physical Condition: Monitored via symptom score. Sacrifice and Analysis: On both the 30th and 60th day of the experiment, the rats were sacrificed by cervical dislocation. Their organs were weighed, and organ damages were examined. Results: D-Galactose administration in rats boosted Iba-1 and CD3 positive cells, but did not improve cognitive impairment or amyloid β protein deposition, resulting in sarcopenia and heart damage in AD model albino rats. Discussion: The study demonstrated that continuous brain exposure to D-Galactose leads to sarcopenia and cardiac injury in AD model rats. However, this exposure did not exacerbate cognitive impairment or lead to amyloid β protein deposition, suggesting that D-Galactose's impact on systemic organ dysfunction may occur independently of its effects on cognitive function in this AD model

Keywords

Alzheimer's disease, D-Galactose, Brain exposure, Intraperitonial injection

Conclusion

There are numerous pharmaceutical applications for the berry fruit Vitis vinifera. Although the pharmacological activities of roots have been studied previously, leaves and seeds have not. The results of this study show that the hydroalcoholic root extract contains alkaloids, which may be able to treat Alzheimer's disease. Subsequent research ought to be designed to clarify the precise components at the core and determine the whole therapeutic range of RGSE

References

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How to cite this article

H. Rama Subba Reddy, M. Vijaya Kumar and V. Uday Kiran (2023). Red Grape Seed Extract (RGSE) has a Positive Effect on Systemic Organ Dysfunctions Caused by Long-Term Exposure to D-galactose (IP) in the Alzheimer's Disease Rat Model. Biological Forum – An International Journal, 15(6): 904-907.