Post- surgical Infections and Associated Bacteria: A Study on Antibiotic Resistance Profiles of Bacterial Isolates

Author: Sumedh P. Narwade, S.B. Mali and R.M. Khobragade

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Abstract

Surgical site infections (SSIs) are significant postoperative complications associated with increased morbidity, prolonged hospital stays, and rising healthcare costs. This study investigated the microbial diversity and antibiotic resistance profiles of pathogens isolated from SSIs in post-operative patients between January 2022 and June 2022. A total of 90 wound samples were analyzed, yielding 150 bacterial isolates. Among these, Gram-negative rods were the most prevalent (39%), followed by Gram-negative cocci (31%). Gram-positive isolates accounting for 30%. Antibiogram analysis focused on the 10 most resistant isolates from each group. Among Gram-positive isolates, SN 81 exhibited the highest resistance, with 88% resistance to tested antibiotics. Among Gram-negative isolates, SN 123 showed the highest resistance at 94%, particularly against carbapenems and cephalosporins. These findings highlight the critical need for robust infection control practices, surveillance of resistance patterns, and the development of tailored therapeutic strategies to combat antimicrobial resistance in healthcare settings.

Keywords

Surgical site infections, antimicrobial resistance, antibiogram

Conclusion

This study underscores the growing challenge posed by multidrug-resistant organisms in surgical site infections (SSIs). Gram-negative isolates exhibited alarming resistance rates, with SN 123 showing the highest resistance at 94%, highlighting the threat posed by extensively drug-resistant strains. Among Gram-positive isolates, SN 81 demonstrated the highest resistance at 88%, reflecting the persistent challenge of treating infections caused by pathogens like Staphylococcus aureus. These findings call for urgent action, including the implementation of antimicrobial stewardship programs, adherence to infection control protocols, and continued research into novel therapeutic strategies. Addressing these challenges is essential to improving surgical outcomes and mitigating the impact of antimicrobial resistance on global healthcare.

References

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How to cite this article

Sumedh P. Narwade, S.B. Mali and R.M. Khobragade (2023). Post- surgical Infections and Associated Bacteria: A Study on Antibiotic Resistance Profiles of Bacterial Isolates. Biological Forum – An International Journal, 15(3): 941-946