Regio- and Diastereoselective Synthesis of Novel Spiro/Dispiro Heterocycles

Author: Suman Shaktawat, Arpita Matta, Akash Kalundha, Narendra Singh Chundawat and Girdhar Pal Singh

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Abstract

The regio- and diastereoselective synthesis of novel spiro/dispiro heterocyclic derivatives was achieved using fluorous solvents, which facilitated enhanced selectivity and efficiency in the reaction processes. This methodology capitalizes on the unique properties of fluorous solvents to control the stereochemistry and regioselectivity of the heterocyclic rings, resulting in the formation of a range of spiro and dispiro compounds. The synthesized derivatives were rigorously characterized using various spectroscopic techniques, including NMR, IR, and mass spectrometry. In addition, the antimalarial activity of the newly synthesized compounds was evaluated against Plasmodium falciparum strains. The compounds 4b and 4e show the most promising antimalarial activity, which are comparable to or slightly better than the standard

Keywords

Diastereoselective, Regioselective, Synthesis, Antimalarial

Conclusion

All the compounds Synthesized by cycloaddition reaction of the reactant with optimal solvent, we investigated that in different solvents all the compounds show 90% yield

References

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How to cite this article

Suman Shaktawat, Arpita Matta, Akash Kalundha, Narendra Singh Chundawat and Girdhar Pal Singh (2023). Regio- and Diastereoselective Synthesis of Novel Spiro/Dispiro Heterocycles. Biological Forum – An International Journal, 15(6): 1030-1034.