Formulation, Development and Characterization of Microsponges of Flutrimazole

Author: Yogesh Kumar Garg and Amit Bhargava

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Abstract

Flutrimazole, recognized for its broad-spectrum antifungal properties, encounters challenges including low solubility and restricted skin penetration, which ultimately impact its therapeutic effectiveness. This study aims to address these challenges by concentrating on the formulation, development, and characterization of microsponges that encapsulate Flutrimazole, thereby enhancing drug delivery efficacy. The microsponges were synthesized through a quasi-emulsion solvent diffusion technique, with optimization focused on various parameters including particle size, drug entrapment efficiency, surface morphology, and in vitro drug release profiles. The formulations that were meticulously prepared underwent evaluation through scanning electron microscopy (SEM) to analyze their structure, differential scanning calorimetry (DSC) to investigate their thermal properties, and Fourier-transform infrared spectroscopy (FTIR) to examine the chemical interactions present. The in vitro drug release investigations revealed a meticulously regulated and prolonged release pattern, indicating improved permeation and retention within the layers of the skin

Keywords

Flutrimazole, Antifungal, Microsponges, Gel, Formulation

Conclusion

The results highlight the potential of microsponge delivery systems for the topical administration of Flutrimazole, offering controlled release, reduced irritation, and potentially enhanced therapeutic outcomes

References

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How to cite this article

Yogesh Kumar Garg and Amit Bhargava (2023). Formulation, Development and Characterization of Microsponges of Flutrimazole. Biological Forum – An International Journal, 15(6): 1035-1046