A series of 4H-1,2,4-triazole-5-(4-Bromophenoxymethyl)- 3-(4-substitutedBenzyl) sulfide derivative (6a-6g) were designed and prepared. The structures have been confirmed using FT-IR spectroscopy, elemental analysis and H1NMR. Antibacterial study was done using gram +ve ( Staphylococcus aureus, and Bacillus cereus) and gram -ve microorganisms (E. coli and Pseudomonas aeruginosa) and disc diffusion method for evaluation of antibacterial activity. Compound 6d showed the highest effect, while compound 6a showed the lowest. All of the prepared compound has antibacterial activity, but none of them has higher effect than the standard Cefuroxime.

1,2,4-triazole, antibacterial, sulfide

All of the previously prepared compounds have a variable antibacterial activity depending on the type of the substituent. It seems that electron withdrawal group may lead to increase the antibacterial activity.

Mazin Nadhim Mousa (2016). Synthesis, Characterization, and Biological Evaluation of Antibacterial Activity of 4H-1,2,4-triazole-5-(4-Bromophenoxymethyl)- 3-(4- substituted Benzyl) sulfide, Biological Forum – An International Journal 8(2): 285