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Synthesis, Characterization and Biological Evaluation of Benzylidenes and ꞵ- Lactams Bearing Aza Heterocyclic Moieties

Author: Diksha Verma, Sunita Sharma, Tanvi Sahni, Amanpreet Kaur and Harleen Kaur

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Abstract

One of the most promising challenges faced by agriculturists is the control of crops against the attack of pathogens. To overcome this, various fungicides like Carbendazim and Mancozeb has been used due to the presence of potential nuclei, nitrogen. In the light of importance of nitrogen nuclei, present study was carried out with the synthesis of benzylidenes 1-7 by reacting different aza heterocyclic amines and iso vanillin followed by synthesis of β-lactams 8-9 using chloroacetyl chloride that carried the cyclization of CH=N moiety in benzylidenes of 1 and 5 compounds. Structural elucidation of the synthesized compounds using various spectroscopic techniques viz. UV-Visible, IR, 1H NMR, and 13C NMR along with their elemental analysis was done. Synthesized compounds were biologically evaluated as antioxidants using phosphomolybdate assay and ascorbic acid as standard. In addition to this, fungitoxicity of the compounds was evaluated against pathogenic strains Rhizoctonia solani, Macrophomina phaseolina, Fusarium verticillioides, and Dreschlera maydis. It was found that compound 1 was most effective against Rhizoctonia solani and Macrophomina phaseolina while compound 6 was effective against Fusarium verticillioides. Compound 8 was proved better antioxidant as compared to other derivatives. Henceforth, the present study highlighted the biological importance of aza heterocycles.

Keywords

Aza heterocycles, Benzylidenes, β-lactams, phosphomolybedate, Rhizoctonia solani, Macrophomina phaseolina, Fusarium verticillioides, and Dreschlera maydis.

Conclusion

In conclusion, we designed various benzylidene derivatives of iso vanillin using aza heterocyclic amines followed by their characterization. Antifungal and antioxidant potential of the synthesized derivatives were also done along with their statistical analysis. It was observed that compound 1 exhibited better antifungal potential against three maize fungal strains viz. R. solani, D. maydis and M. phaseolina while compound 6 gave better result against F. verticillioides. Compounds 8 (β-lactam ring with triazole moiety) displayed better antioxidant potential at all the concentrations. Thus, it can be concluded that triazole moiety has remarkable potential to be used as antifungal and antioxidant agents.

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How to cite this article

Diksha Verma, Sunita Sharma, Tanvi Sahni, Amanpreet Kaur and Harleen Kaur (2022). Synthesis, Characterization and Biological Evaluation of Benzylidenes and Β-Lactams Bearing Aza Heterocyclic Moieties. Biological Forum – An International Journal, 14(3): 1017-1024.