Synthesis, Molecular Docking and Cytotoxic Activity of Some Novel Semicarbazone Derivatives

Author: Shivani Dhariwal and Hemendra Pratap Singh

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Abstract

Semicarbazone derivatives have gained significant attention in medicinal chemistry due to their diverse biological activities, including anticancer properties. In this study, we report the synthesis of novel semicarbazone derivatives using a simple and efficient condensation reaction between semicarbazide and various substituted aldehydes or ketones. The synthesized compounds were characterized using spectroscopic techniques such as NMR, and mass spectrometry to confirm their structural integrity. Molecular docking studies were conducted to assess the binding affinity of these derivatives with key cancer-associated protein targets. The docking results revealed strong interactions with active site residues, suggesting their potential as anticancer agents. Furthermore, the cytotoxic activity of the synthesized compounds was evaluated against selected cancer cell lines. Several derivatives exhibited significant cytotoxicity, with IC₅₀ values comparable to standard anticancer drugs. The findings highlight the potential of these novel semicarbazone derivatives as promising candidates for anticancer drug development

Keywords

Semicarbazone derivatives, synthesis, molecular docking, cytotoxicity, anticancer activity

Conclusion

The study suggests that compounds 3h and 3l exhibit the most promising cytotoxic activity against all tested cancer cell lines, making them potential lead molecules for further anticancer drug development. Compounds 3b, 3d, 3e, and 3j also demonstrate good activity, warranting further investigation

References

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How to cite this article

Shivani Dhariwal and Hemendra Pratap Singh (2023). Synthesis, Molecular Docking and Cytotoxic Activity of Some Novel Semicarbazone Derivatives. Biological Forum – An International Journal, 15(5): 1795-1801