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The Correlation between KCNJ11 rs5215 Gene Polymorphism and Type 2 Diabetes Mellitus in Northern Population

Author: Shubhangi Chaturvedi, Shivangi Singh, Pooja and Dinesh Raj Modi

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Abstract

Type 2 diabetes mellitus (T2DM) is known as a multifactorial disease that develops as a result of the interplay between various susceptibility genes and environmental components. KCNJ11 gene codes for the voltage-gated potassium channels that are responsible for glucose-stimulating insulin release. The major challenge faced during the study is the collection of samples from patients and the greater number of samples has to be processed to make the significance of this study more fruitful. The Aim of this study is to find the association between KCNJ11 gene rs5215 polymorphism and T2DM in the North Indian Population. This is a case- control study. The KCNJ11 associated rs5215 polymorphism has been genotyped using Restriction Fragment Length Polymorphism (RFLP) technique. The incidence of K allele was founded more in the group of patient, and the prevalence of EK genotype was founded more in the control group of individuals. The recessive model genotype TT was founded to be remarkably associated with the occurrence of T2DM. This study conveyed the association of KCNJ11 gene polymorphism rs5215 as a possible reason to cause T2DM.

Keywords

KCNJ11, RFLP, Polymorphism, Type 2 Diabetes mellitus, Potassium channel, North India

Conclusion

The research found a link between type 2 diabetes mellitus and the KCNJ11 gene's rs5215 polymorphism in a sample of the North Indian Population. This research bolsters the pathophysiology of T2DM's KCNJ11 rs5215 polymorphism. During the work of this study collection of samples from Diabetic patients has been a major challenge, but we counsel patients about the study and then take their consent to take blood samples. The important contribution has been made by us is to increase the sample size which increased the relevance of this study. Bigger investigations need to be conducted to verify this finding.

References

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How to cite this article

Shubhangi Chaturvedi, Shivangi Singh, Pooja and Dinesh Raj Modi (2023). The Correlation between KCNJ11 rs5215 Gene Polymorphism and Type 2 Diabetes Mellitus in Northern Population. Biological Forum – An International Journal, 15(4): 678-683.