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The Effect of Raloxifene given in Post Menopausal Osteoporosis against the effects of Anti-Epileptics with the help of DEXA analysis and other Pathways

Author: Sagarika Kabra, A.K.S. Rawat and Pranay Wal

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Abstract

The disease Epilepsy is known to be a common neurological disorder which is affecting majority of population in the whole world. The disease is caused due to many factors which includes abnormalities in brain, stroke, head injury, drug abuse, brain infection. Therefore, to treat such kind of disorders anti-epileptic drugs are used in major as well as minor quantity. By take excessive intake of anti-epileptic drugs it has shown to reduce bone density and bone mineral concentration in people who are taking these drugs on regular basis. As Anti-Epileptic Drugs have been known to be in association with negative impact on the bone health which leads to many kinds of bone disorders. Many kinds of biochemical abnormalities of bone metabolism are seen in patients taking these drugs. There were many kinds of challenges faced during the study as the Bone Mineral Density done using DEXA analysis was the measurement of soft tissue that is changes in femur and lumbar vertebrae. There was a contribution seen by the university in terms of apparatus/chemicals and other necessary requirements. As if by seeing all the negative values it is found that the drug named Raloxifene has found to be a pre-eminent gem which has reduced the chances of bone density and other bone related disorders.

Keywords

Raloxifene, Anti-epileptic, DEXA, Sodium Valproate, Phenytoin

Conclusion

The above results show that Raloxifene helps to prevent and treat the bone loss which is caused due to Phenytoin & Sodium Valproate as they showed a great changes of side effects on bone health and as well showed how this drug helped to prevent or stop seizures. It is shown that how raloxifene has the ability to survive from status epilepticus in female mice.

References

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How to cite this article

Sagarika Kabra, A.K.S. Rawat and Pranay Wal (2023). The Effect of Raloxifene given in Post Menopausal Osteoporosis against the effects of Anti-Epileptics with the help of DEXA analysis and other Pathways. Biological Forum – An International Journal, 15(4): 20-24.