Thymoquinone Attenuates Hematological and Biochemical Alterations Induced by Potassium Bromate Toxicity in Female Albino Mice, Mus musculus

Author: Neetu Patel, Renu Shrivastava and Vinoy K. Shrivastava

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Abstract

It has never been demonstrated that thymoquinone (TQ), the primary active component of the essential oil present in N. sativa seed, protects against the deterioration of blood indices brought on by potassium bromate (KBrO3). Consequently, the objective of this work was to examine Potential protective effects of TQ against KBrO3-induced biochemical and haematological changes in female albino mice. TQ's ability to protect female albino mice against KBrO3-induced haematological and biochemical changes was investigated in this work. We employed 24 mature, female albino mice (Mus musculus) in this investigation. For 60 days, they were separated six animals each, divided into four groups Control group (20 mg/kg b.w. dissolved in vehicle corn oil), the KBrO3 group (100 mg/kg b.w. dissolved in double distilled water), the KBrO3 + TQ group (100 mg/kg b.w. dissolved in double distilled water along with 20 mg/kg body weight dissolved in vehicle corn oil) and the TQ group (20 mg/kg b.w. dissolved in vehicle corn oil). Throughout this inquiry, blood metabolites were examined to see how KBrO3 affected several haematological, enzymatic, and oxidative stress indicators as well as glucose, cholesterol and lipid metabolism. In addition, we compared TQ's ability to counteract KBrO3 toxicity and lessen the disruption of serum homeostasis. We discovered in the present study that TQ was significantly enhanced the haematological parameters like total RBCs count (p≤0.001), WBCs total count (p≤0.001), and haemoglobin level (p≤0.001) along with SOD (p≤0.001), CAT (p≤0.01) and GPx (p≤0.01) and high density-lipoprotein HDL (p≤0.001), on the other hand TQ remarkably lowered the serum glucose (p≤0.001), cholesterol (p≤0.001), triglycerides (p≤0.001), and LDL (p≤0.001) and platelets count (p≤0.001) along with Aspartate aminotransferase (AST) (p≤0.001) Alanine aminotransferase (ALT) (p≤0.001), and Alkaline phosphatase (ALP) (p≤0.001), as compared to KBrO3 group. The findings show that TQ ca treat hematological, biochemical, and oxidative changes brought on by KBrO3 poisoning.

Keywords

Potassium bromate, Thymoquinone, Hematology, Oxidative stress and Hepatic marker

Conclusion

It is clear that TQ ameliorated the toxic effect of Potassium bromate and suppressed the oxidative stress induced in mice through its antioxidant mechanism and overall significantly positive effect on the numerous parameters considered.

References

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How to cite this article

Neetu Patel, Renu Shrivastava and Vinoy K. Shrivastava (2023). Thymoquinone Attenuates Hematological and Biochemical Alterations Induced by Potassium Bromate Toxicity in Female Albino Mice, Mus musculus. Biological Forum – An International Journal, 15(4): 710-716.